担当科目（学部）

・生命の化学（臨床検査学科、理学療法学科、作業療法学科、はり灸・スポーツトレナ―学科、ヘルスプロモーション整復学科）
・分析化学（臨床検査学科）

出身校

大阪大学

学 位

理学博士

専門分野（相談可能な分野）

・活性酸素およびフリーラジカル
・機器分析（NMR、MS、ESR、可視・紫外吸収スペクトル等）

現在または未来の研究テーマなど

フリーラジカルの構造決定とその生成に影響を与える天然物質の検索

研究のキーワード

フリーラジカル、活性酸素、HPLC、ESR、HPLC-ESR-MS

所属学会

日本生化学会、日本酸化ストレス学会

社会活動など

・日本生化学会評議員
・日本酸化ストレス学会評議員

オフィスアワー

月曜日・金曜日（12時20分～13時10分）

主な研究業績

・Radical formation in individual aqueous solutions of some unsaturated fatty acids and in their mixtures. Matsui Y, Iwahashi H., J Clin Biochem Nutr. 2018, 63, 90-96.
・Detection of protonated non-Watson-Crick base pairs using electrospray ionization mass spectrometry. Ishida R, Iwahashi H., J Biochem. 2018,163, 215-222.
・Oxygen-Centered Radicals Formed in the Reaction Mixtures Containing Chloroiron Tetraphenylporphyrin, Iodosylbenzene, and Ethanol. Nishizaki D, Iwahashi H., Inorg Chem. 2017, 56, 13166-13173.
・Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions. Asano M, Iwahashi H. Eur J Med Chem. 2017, 127, 740-747.
・High performance liquid chromatography/electron spin resonance/mass spectrometry analyses of radicals formed in an anaerobic reaction of 9- (or 13-) hydroperoxide octadecadienoic acids with ferrous ions. Iwahashi H, Hirai T, Kumamoto K., J Chromatogr A, 2006, 1132, 67-75.
・Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. Iwahashi H, Nishizaki K, Takagi I. Biochem J. 2002, 361, 57-66.
・High-performance liquid chromatographic determination of linoleic acid peroxide-derived radicals using electrochemical detection. Iwahashi H. J Chromatogr A. 2000, 904, 197-202.
・Some polyphenols inhibit the formation of pentyl radical and octanoic acid radical in the reaction mixture of linoleic acid hydroperoxide with ferrous ions. Iwahashi H.Biochem J. 2000, 346, 265-273.
・1:1 Complex of guanine quartet with alkali metal cations detected by electrospray ionization mass spectrometry.Fukushima K, Iwahashi H. Chem. Commun. 2000, 895-896.
・Detection of the oxidative products of 3-hydroxykynurenine using high-performance liquid chromatography-electrochemical detection-ultraviolet absorption detection-electron spin resonance spectrometry and high-performance liquid chromatography-electrochemical detection-ultraviolet absorption detection-mass spectrometry
H. Iwahashi, T. Ishii; J. Chromatogr. A, 773, 23-31 (1997)
・α-(4-pyridyl-1-oxide)-N-tert-butylnitron radical adduct using high-performance liquid chromatography with electrochemical detection
H.Iwahashi; J. Chromatogr. A, 753, 235-242 (1996).
・Quantitative detection of reduced, radical and oxidized forms of α-(4-pyridyl-1-oxide)-N-tert-butylnitron radical adduct using high-performance liquid chromatography with electrochemical detection
H. Iwahashi; J. Chromatogr. A, 753, 235-242 (1995)
・Combined liquid chromatography/electron paramagnetic resonance spectrometry/ ionization mass spectrometry for radical identification
H.Iwahashi, C. Parker, R. Mason, K. Tomer; Anal. Chem., 64, 2244-2252 (1992)
・Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical, and 14, 15-epoxyarachidonic acid radical: identification by h.p.l.c.-e.p.r.and LC/TSP/MS
H.Iwahashi, C. Parker, R. Mason, K. Tomer; Biochem. J., 276, 447-453 (1991)
・The effects of caffeic acid and its related catechols on hydroxyl radical formation by 3-hydroxyanthranilic acid, ferric chloride, and hydrogen peroxide
H.Iwahashi, T. Ishii, R. Sugeta, R. Kido; Arch. Biochem. Biophys., 276, 242-247 (1990)
・Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen
H.Iwahashi, T. Ishii, R. Sugeta, R. Kido; Biochem. J., 251, 893-899 (1988)
・Inhibition by chlorogenic acid of haematin-catalysed retinoic acid 5,6-epoxidation
H.Iwahashi, Y. Negoro, A. Ikeda, H. Morishita, R. Kido; Biochem. J., 239, 641-646 (1986)
・Detection of radical species in haematin-catalysed retinoic acid 5,6-epoxidation by using h.p.l.c.-e.s.r. spectrometry
H.Iwahashi, A. Ikeda, Y. Negoro, R. Kido; Biochem. J., 236, 509-514 (1986)
・Haemoglobin-catalysed retinoic acid 5,6-epoxidation
H.Iwahashi, A. Ikeda, R. Kido; Biochem. J., 232, 459-466 (1985)/li>
・Proton exchange between nucleic acid bases in nonaqueoussolvents
H.Iwahashi, Y. Kyogoku; J. Am. Chem. Soc., 102, 2913-2917 (1980)
・Direct proton exchange between complementary nucleic acid bases
H.Iwahashi, Y. Kyogoku; Nature, 271, 277-278 (1978)
・Detection of proton acceptor sites of hydrogen bonding between nucleic acid bases by the use of 13C magnetic resonance
H.Iwahashi, Y. Kyogoku; J. Am. Chem. Soc., 99, 7761-7765 (1977)