大瀧 博文
おおたき ひろふみ





岐阜大学大学院 医学系研究科医科学専攻博士課程 修了
大阪大学 医学部保健学科 卒業
藤田保健衛生大学短期大学 衛生技術科 (現 藤田医科大学)  卒業












・日本臨床検査学教育協議会 理事
・日本臨床微生物学会 評議員
・大阪府臨床検査技師会 学術部 微生物検査部門 世話人




Vα14 NKT cells activated by α-galactosylceramide augment
lipopolysaccharide-induced nitric oxide production in mouse intra-hepatic lymphocytes.
Ohtaki H, Ito H, Ando K, Ishikawa T, Saito K, Imawari M, Yokochi T, Moriwaki H,
Seishima M.
Biochem Biophys Res Commun. 378(3): 579-583, 2009

First report of acute cholecystitis with sepsis caused by Cellulomonas denverensis.
Ohtaki H, Ohkusu K, Sawamura H, Ohta H, Inoue R, Iwasa J, Ito H, Murakami N, Ezaki T, Moriwaki H, Seishima M.
J Clin Microbiol. 47(10):3391-3393, 2009

Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Vα14 NKT cells.
Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Tanaka R, Osawa Y, Yokochi T, Moriwaki H, Saito K, Seishima M.
Biochem Biophys Res Commun. 389(2): 229-234, 2009

The absence of IDO up-regulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.
Hoshi M, Saito K, Hara A, Taguchi A, Ohtaki H, Tanaka R, Fujigaki H, Osawa Y, Takemura M, Matsunami H, Ito H, Seishima M.
J Immunol. 185(6):3305-3312, 2010

Ability of IDO to attenuate liver injury in α-galactosylceramide-induced hepatitis model.
Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A,
Moriwaki H, Saito K, Seishima M.
J Immunol. 185(8): 4554-4560, 2010

L-Tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin.
Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A,
Nagaki M, Moriwaki H, Saito K, Seishima M.
J Biol Chem. 286(40): 34800-34808, 2011

L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice.
Hoshi M, Matsumoto K, Ito H, Ohtaki H, Arioka Y, Osawa Y, Yamamoto Y,
Matsunami H, Hara A, Seishima M, Saito K.
J Immunol, 188(8):3980-3987, 2012.

High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice.
Ohtaki H, Ito H, Hoshi M, Osawa Y, Takamatsu M, Hara A, Ishikawa T, Moriwaki H, Saito K, Seishima M.
Sci Rep, 2:367, 2012.

A case of sepsis caused by Streptococcus canis in a dog owner: a first case report of sepsis without dog bite in Japan.
Ohtaki H, Ohkusu K, Ohta H, Miyazaki T, Yonetamari J, Usui T, Mori I, Ito H,
Ishizuka T, Seishima M.
J Infect Chemother, 19:1206-1209, 2013.

Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes.
Ando T, Ito H, Ohtaki H, Seishima M.
Sci Rep, 3:2559, 2013.

Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis.
Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M.
Biochim Biophys Acta. 1842: 1464-1471, 2014.

Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal Cells.
Hoshi M, Osawa Y, Ito H, Ohtaki H, Ando T, Takamatsu M, Hara A, Saito K,
Seishima M.
Infect Immun. 82: 4487-4495, 2014.

Role of invariant NKT cells in lipopolysaccharide-induced lethal shock during encephalomyocarditis virus infection.
Ando T, Ito H, Ohtaki H, Kanbe A, Hirata A, Hara A, Seishima M.
Immunobiology, 222: 350-357, 2017.

Draft genome sequence of Streptococcus canis clinical strain OT1, isolated from a dog owner with invasive infection without a dog bite in Japan.
Yoshida H, Katayama Y, Fukushima Y, Ohtaki H, Ohkusu K, Mizutani T, Takahashi T.
Microbiol Resour Announc, 8(39): e00770-19, 2019.

First report of the local spread of vancomycin-resistant Enterococci ascribed to the interspecies transmission of a vanA gene cluster-carrying linear plasmid.
Hashimoto Y, Kita I, Suzuki M, Hirakawa H, Ohtaki H, Tomita H.
mSphere, 5(2):e00102-20, 2020.

Evaluation of presumptive identification of Enterobacterales using CHROMagar Orientation medium and rapid biochemical tests.
Ohtaki H, Takahashi A, Niwa A, Yonetamari J, Nakayama A, Kuchibiro T, Ohta H, Ito H, Baba H, Murakami N, Ohkusu K.
J Clin Lab Anal, 34(10): e23453, 2020.